Related Experiment Video
Updated: Jun 10, 2025
05:38
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
36
[Deposits: Basic lesions and frequent deposits]
1Service d'anatomie et de cytologie pathologiques, CHU de Nîmes, place du Pr-Debré, 30029 Nîmes, France; Institut de recherche en cancérologie de Montpellier, U1194, Montpellier, France.
Annales De Pathologie
|October 17, 2024
Summary
Deposit diseases involve abnormal substance buildup in the body. Pathologists use various diagnostic tools to identify and classify these heterogeneous conditions.
Area of Science:
- Pathology
- Cell Biology
- Biochemistry
Background:
- Deposit diseases are a diverse group of conditions.
- Characterized by pathological accumulation of substances within cells or extracellularly.
- The origin of accumulated substances can be endogenous or exogenous.
Purpose of the Study:
- To highlight the heterogeneity of deposit diseases.
- To emphasize the crucial role of pathologists in diagnosis.
- To outline the diagnostic methods available for deposit diseases.
Main Methods:
- Special stains
- Immunohistochemistry
- Immunofluorescence
- Electron microscopy
- Proteomics
Main Results:
- Pathologists utilize a range of techniques for diagnosis and classification.
- Diagnostic tools include both traditional and advanced methods.
- Accurate diagnosis is essential due to varying consequences based on affected tissues.
Conclusions:
- Pathological deposit accumulation defines a broad category of diseases.
- A multidisciplinary approach involving various diagnostic techniques is necessary.
- Understanding deposit disease pathophysiology is key to patient outcomes.
Related Concept Videos
01:25Endocarditis II: Clinical features and Diagnostic Tests
2
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
01:22Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
01:30Skin Cancer
3.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.9K
01:24Chronic Kidney Disease II: Clinical Manifestations
2
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
2
01:23Skin Diseases and Disorders
3.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.7K
01:17Chronic Bowel Disorders: Introduction
397
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
397