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Transcriptome wide changes in long noncoding RNAs in diabetic ischemic heart disease.

Amit Kumar Rai1,2, Natarajaseenivasan Suriya Muthukumaran1,2, Noemi Nisini1,2

  • 1Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, 19140, USA.

Cardiovascular Diabetology
|October 17, 2024
PubMed
Summary

Diabetic ischemic heart disease involves altered long noncoding RNAs (lncRNAs). Downregulation of Gm19522 and Gm8075 post-myocardial infarction suggests they may be novel therapeutic targets for diabetic heart conditions.

Keywords:
Db/db miceDiabetesIschemic heart diseaseLong noncoding RNATranscriptome

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Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Genomics

Background:

  • Type 2 diabetes mellitus (DM) significantly increases ischemic heart disease risk.
  • The molecular mechanisms underlying diabetic ischemic heart disease are not fully understood.
  • Long noncoding RNAs (lncRNAs) play roles in cardiovascular conditions, but their function in diabetic heart disease is unclear.

Purpose of the Study:

  • To investigate lncRNA expression profiles in a mouse model of type 2 diabetes with ischemic heart disease.
  • To identify specific lncRNAs that are differentially expressed after myocardial infarction (MI) in diabetic mice.

Main Methods:

  • Unbiased RNA sequencing was performed on left ventricular (LV) tissues from type 2 DM (db/db) and control (db/+) mice subjected to sham or MI surgery.
  • Computational analysis identified differentially expressed lncRNAs between groups.

Main Results:

  • Several lncRNAs were differentially expressed in diabetic mice after MI compared to controls.
  • Gm19522 and Gm8075 were identified as significantly downregulated post-MI in diabetic mice.
  • Gm19522 is potentially involved in DNA replication, while Gm8075 is linked to cancer gene dysregulation and PI3K/Akt pathways.

Conclusions:

  • The identified lncRNAs, Gm19522 and Gm8075, show altered expression in diabetic ischemic heart disease.
  • These lncRNAs may serve as potential biomarkers for cardiac repair or novel therapeutic targets in diabetic ischemic heart disease.