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MAPbrain: a multi-omics atlas of the primate brain
Liangchen Zhuo1,2, Mengdi Wang1,2, Tingrui Song1
1Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Nucleic Acids Research
|October 18, 2024
Summary
MAPbrain is a new multi-omics atlas for primate brain development. It integrates diverse datasets to explore gene expression and cell types across species and life stages, aiding neurological disorder research.
Area of Science:
- Neuroscience
- Genomics
- Developmental Biology
Background:
- Brain development is a lifelong, genetically guided process crucial for cognitive functions and understanding neurological disorders.
- Multi-omics techniques offer comprehensive insights but pose data integration and analysis challenges.
Purpose of the Study:
- To introduce MAPbrain, a multi-omics atlas of the primate brain, designed to facilitate the exploration of brain development.
- To provide a robust platform for integrating and analyzing diverse multi-omics data from primate brains.
Main Methods:
- Integration and normalization of published and public multi-omics data (transcriptomics, epigenomics, spatial transcriptomics).
- Inclusion of data from 21 million brain cells across 38 brain regions and 436 sub-regions.
- Data collection across embryonic and adult stages, with 164 time points in humans and non-human primates.
Main Results:
- MAPbrain offers an interactive platform for exploring cell type- and time point-specific markers.
- The atlas enables gene expression comparisons across brain regions, species, and developmental stages.
- Joint analyses of transcriptome and epigenome data are facilitated, along with cross-species cell type navigation.
Conclusions:
- MAPbrain provides a valuable resource for comprehensive brain development research.
- The platform supports in-depth analysis of gene regulation and cell diversity in the primate brain.
- An integrated online module allows users to analyze their own data within the MAPbrain framework.
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