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Updated: Jun 10, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
Published on: March 18, 2014
[Corrigendum] Nucleosome‑binding protein HMGN2 exhibits antitumor activity in human SaO2 and U2‑OS osteosarcoma cell
Guojun Liang1, Enjie Xu2, Chaoqun Yang2
1Department of Spine Surgery, Xinchang People's Hospital, Xinchang, Zhejiang 312500, P.R. China.
Abstract:
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 5A on p. 1305, the same xenograft tumor image had been selected for a pair of the GFP/U2‑OS experiments, where the images from discretely performed experiments were intended to have been shown. Furthermore, upon performing an independent analysis of the data in the Editorial Office, it was noted that the data selected for the 'SaO2/GFP/24 h' and 'SaO2/HMGN2/48 h' experiments in Fig. 4A, also on p. 1305, were strikingly similar, such that the same data had apparently been chosen to show the results of differently performed experiments. After having inspected the figures, the authors realized that one of the n=3 experimental results had inadvertently been omitted from Fig. 5A, and the data shown to represent the 'SaO2/GFP/24 h' experiment had been chosen incorrectly. The revised and corrected versions of Figs. 4 and 5 are shown on the next page (also note that erroneously written labels have been corrected in Fig. 5C: "Tumor volume" has been replaced by "Tumor weight"). Note that the errors made in terms of the assembly of the data in these figures did not affect the overall conclusions reported in the paper. The authors are grateful to the Editor of Oncology Reports for granting them this opportunity to publish a Corrigendum, and apologize to boh the Editor and the readership for any inconvenience caused. [Oncology Reports 33: 1300‑1306, 2015; DOI: 10.3892/or.2014.3689].
Insights
This corrigendum addresses image and data duplication errors in figures concerning xenograft tumor experiments. Corrected figures are provided, ensuring no impact on the study's overall conclusions regarding GFP/U2-OS and SaO2 experiments.
Area of Science:
- Oncology Research
- Experimental Pathology
- Biomedical Imaging
Context:
- The original study investigated xenograft tumor growth and response to specific experimental conditions.
- Concerns were raised regarding the accurate representation of experimental data in published figures.
Purpose:
- To correct errors in figure assembly identified post-publication.
- To ensure the integrity and accurate depiction of experimental results.
Summary:
- Identified instances of duplicated xenograft tumor images in Fig. 5A and similar data sets for distinct experiments in Fig. 4A.
- Corrected figures include revised images and data, along with corrected labels (e.g., 'Tumor weight' instead of 'Tumor volume').
- An omitted experimental result from Fig. 5A has been included, and incorrect data for the 'SaO2/GFP/24 h' experiment was replaced.
Impact:
- The corrigendum rectifies data presentation issues without altering the fundamental conclusions of the original research.
- Ensures clarity and accuracy for readers and future research referencing the study.
- Upholds scientific integrity by addressing and correcting errors in published data.

