Related Experiment Video
Updated: Jun 10, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Transition Metal-Catalyzed C-H Activation/Functionalization of 8-Methylquinolines
Fatemeh Doraghi1, Mohammad Mahdi Aghanour Ashtiani1, Mahmoud Ameli2
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
8-Methylquinoline is regarded as an ideal substrate to participate in diversely C(sp3)-H functionalization reactions. The presence of the chelating nitrogen atom enables 8-methylquinoline to easily form cyclometallated complexes with various transition metals, leading to the selective synthesis of functionalized quinolines. Considering the great importance of quinoline cores in medicinal chemistry, in this review article, we have covered the publications related to the C-H activation and functionalization of 8-methylquinoline under transition metal catalysis during the last decade.
More Related Videos
Related Concept Videos
Cycloaddition Reactions: MO Requirements for Thermal Activation
Cycloaddition Reactions: MO Requirements for Photochemical Activation
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Properties of Organometallic Compounds
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...

