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Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for In Vitro Release Testing: Development

Naresh Mittapelly1, Alexandre Djehizian1, Krishna Chaitanya Telaprolu1

  • 1Certara Predictive Technologies (CPT), Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield S1 2BJ, U.K.

ACS Applied Bio Materials
|October 18, 2024
PubMed
Summary

A new mechanistic model predicts drug release from polylactide coglycolide (PLGA) implants by analyzing critical quality attributes and release processes. This model aids in optimizing PLGA formulation design for effective drug delivery.

Keywords:
PLGA-based solid implantsbiodegradable implantsin vitro release testinglong-acting injectablesmechanistic modeling

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