Related Experiment Video

Updated: Jun 10, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

8.3K

Elevated liver function tests in infants exposed to elexacaftor-tezacaftor-ivacaftor in utero and while breastfeeding

Theresa Jane Kolaczkowski1, Amanda Bevan2, Julian Legg2

  • 1Wessex Adult Cystic Fibrosis Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|October 18, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Breast milkBreastfeedingCataractDrug-induced liver injuryElexacaftor-tezacaftor-ivacaftorLiver function testPregnancyPregnant

More Related Videos

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

26.3K
Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities
11:00

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

4.2K

Related Experiment Videos

Last Updated: Jun 10, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

8.3K
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

26.3K
Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities
11:00

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

4.2K

Related Concept Videos

Teratogenicity01:07

Teratogenicity

2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

234
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
234

Articles linked to this work by shared authors, journal, and citation graph.

Thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor.

Experimental physiology·2026

Update on pediatric cataract surgery.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)·2025

Real-World Views of Patching Differ to Health Professionals': An Online Survey of Professionals, Patients, Teachers, Parents and Carers.

The British and Irish orthoptic journal·2025

Elexacaftor/tezacaftor/ivacaftor in children aged ≥6 years with cystic fibrosis heterozygous for F508del and a minimal function mutation: results from a 96-week open-label extension study.

The European respiratory journal·2025

Peripheral Muscle Function and Body Composition in People With Cystic Fibrosis on Elexacaftor/Tezacaftor/Ivacaftor: A Cross-Sectional Single-Centre Study.

Pediatric pulmonology·2025

A school-based intervention to improve mental health outcomes for children with cerebral visual impairment (CVI): feasibility cluster randomised trial.

Pilot and feasibility studies·2025

Perspectives on inhaled medicines in the CFTR modulator era: A national survey of adults with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026

Comfort discussing financial challenges and accessing resources in cystic fibrosis care among people with cystic fibrosis and their care partners: A cross-sectional survey study.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026

Timeliness to diagnostic and early care milestones after newborn screening for Cystic Fibrosis in Texas: 14 years of experience at 2 centers.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026

Long-term outcomes of adolescents/adults with CF screen positive, inconclusive diagnosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026

Vanzacaftor/tezacaftor/deutivacaftor partially restores CFTR function of the L467F;F508del complex allele in primary nasal epithelial cells.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026

Extrapulmonary benefits and pharmacogenomics in lung transplant recipients with Cystic Fibrosis on Elexacaftor/Tezacaftor/Ivacaftor (ETI) therapy.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026

Competency Scale for Developmentally Supportive Parenting of High-Risk Infants (CS-DSPHI): Development and Psychometric Testing.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses·2026

Caring for Preterm Infants on Home Oxygen: A Descriptive Qualitative Study of Caregivers' Experiences in Belgium.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses·2026

Reclaiming agency: how women build mood, confidence and social connections during perimenopause.

Climacteric : the journal of the International Menopause Society·2026

The effect of mindfulness-based counseling on shame in women with human papillomavirus.

Psychology, health & medicine·2026

Ophthalmic artery doppler in screening for preeclampsia - a systematic review of current evidence.

Ginekologia polska·2026

Characteristics and in-hospital outcomes of pregnant trauma patients in Japan and the USA: A registry-based study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us