Related Experiment Video
Updated: Jun 10, 2025

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
Published on: May 13, 2019
The Integrator complex: an emerging complex structure involved in the regulation of gene expression by targeting RNA
Tingyue Li1, Fulei Zeng1, Yang Li1
1School of Stomatology, Affiliated Stomatological Hospital, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Abstract:
The Integrator complex is a multisubunit complex that participates in the processing of small nuclear RNA molecules in eukaryotic cells by cleaving the 3' end. In protein-coding genes, Integrator is a key regulator of promoter-proximal pausing, release, and recruitment of RNA polymerase II. Research on Integrator has revealed its critical role in the regulation of gene expression and RNA processing. Dysregulation of the Integrator complex has been implicated in a variety of human diseases including cancer and developmental disorders. Therefore, understanding the structure and function of the Integrator complex is critical to uncovering the mechanisms of gene expression and developing potential therapeutic strategies for related diseases.
Related Concept Videos
RNA Polymerase II Accessory Proteins
Chromatin Structure Regulates pre-mRNA Processing
The chromatin structure, especially...
Co-activators and Co-repressors
General Transcription Factors
Regulation of Expression at Multiple Steps
Master Transcription Regulators

