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Summary
This study investigated presenile dementia of the Alzheimer type (PDAT) in Israel, finding higher incidence in those of European/American origin. Survival was slightly longer for earlier onset, suggesting a unified Alzheimer
Area of Science:
- Neurology
- Epidemiology
- Geriatrics
Background:
- Presenile dementia of the Alzheimer type (PDAT) affects individuals under 60.
- Understanding PDAT epidemiology is crucial for public health.
- Previous studies have not fully characterized PDAT incidence and survival in diverse populations.
Purpose of the Study:
- To conduct a nationwide epidemiologic study of PDAT in Israel.
- To determine the incidence rates, survival patterns, and demographic risk factors for PDAT.
- To explore the relationship between PDAT and senile dementia of the Alzheimer type.
Main Methods:
- Nationwide epidemiologic study using the Israeli National Neurologic Disease Register.
- Review of clinical records of hospitalized patients (1974-1983) with dementia diagnoses.
- Ascertainment of 71 Jewish patients with PDAT onset between 1974-1978.
Main Results:
- Average annual incidence rate of PDAT was 2.4 per 100,000 population (ages 40-60).
- Incidence was significantly higher in individuals born in Europe/America (2.9) versus Africa/Asia (1.4).
- Median survival was 8.1 years; earlier onset (before 55) correlated with slightly longer survival.
Conclusions:
- PDAT incidence in Israel is influenced by geographic origin, with higher rates in European/American-born individuals.
- Survival is not significantly different between origin groups, but earlier onset may prolong life.
- The continuous incidence curve suggests a single underlying disease process for both presenile and senile Alzheimer's dementia.