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Upper airway comorbidities of asthma
Chang-Gyu Jung1, Kathleen M Buchheit2, Grazyna Bochenek3
1Division of Allergy-Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida Morsani College of Medicine, Tampa, Fla; Department of Allergy and Clinical Immunology, Keimyung University School of Medicine, Daegu, Korea.
The Journal of Allergy and Clinical Immunology
|October 19, 2024
Summary
Asthma management improves with the recognition and treatment of upper airway comorbidities (UACs), such as rhinitis and sinusitis. Addressing these linked conditions enhances symptom control and lung function in asthma patients.
Area of Science:
- Pulmonology
- Allergy and Immunology
Background:
- Asthma is a chronic airway disease frequently co-occurring with upper airway comorbidities (UACs).
- The 'one airway, one disease' concept highlights the link between asthma and UACs like rhinitis and chronic rhinosinusitis.
- UACs significantly influence asthma phenotypes and patient outcomes.
Purpose of the Study:
- To emphasize the importance of recognizing and managing UACs in comprehensive asthma care.
- To discuss the impact of UACs on asthma control and quality of life.
- To introduce respiratory biologics as advanced treatment options for asthma with UACs.
Main Methods:
- Review of existing literature on asthma and UACs.
- Analysis of the relationship between UACs and asthma phenotypes.
- Exploration of current and emerging treatment strategies, including biologics.
Main Results:
- UACs are closely associated with asthma and impact its diverse phenotypes.
- Effective management of UACs leads to improved asthma symptom control, lung function, and quality of life.
- Respiratory biologics offer novel therapeutic avenues for complex asthma cases involving UACs.
Conclusions:
- Integrated management of UACs is essential for optimal asthma control.
- Recognizing the interconnectedness of the airways is key to personalized asthma treatment.
- Advancements in respiratory biologics hold promise for patients with severe asthma and comorbid UACs.
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