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Updated: Jun 10, 2025

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
Published on: October 22, 2019
Brain PET Imaging in the Presurgical Evaluation of Drug-Resistant Focal Epilepsy
Anthime Flaus1, Eric Guedj2, Tatiana Horowitz3
1Nuclear Medicine Department, Hospices Civils de Lyon, Medical Faculty of Lyon Est, University Claude Bernard Lyon 1, Lyon, France; Lyon Neuroscience Research Center, INSERM U1028/CNRS UMR5292, Lyon, France.
Abstract:
Presurgical evaluation aims to localize the seizure onset zone (SOZ) for a tailored resection. Interictal [18F]fluorodeoxyglucose PET is now an established test to lateralize and/or localize the SOZ, particularly if MR imaging is negative or if the noninvasive assessment shows discrepancies. PET can show hypometabolic areas associated with SOZ and the potential altered metabolic brain networks. It is very sensitive, and this is increased if images are read coregistered to the patient's MR imaging. PET hypometabolic intensity and pattern show prognostic value.
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