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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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Postictal Rash: A Rare Case Reporting to Neurology.

Hamza Jamil1, Bridgette King2, Rund Radi Haddadin2

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Generalized epileptic seizures can cause a rare pinpoint rash. This postictal skin manifestation, appearing after seizures, resolved when the seizures were controlled, aiding diagnosis.

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Area of Science:

  • Neurology
  • Dermatology

Background:

  • Epileptic seizures often result in a postictal phase with neurological symptoms like confusion and lethargy.
  • Cutaneous manifestations are rare but documented occurrences following generalized epileptic seizures.

Observation:

  • A 45-year-old male presented with a pinpoint, non-blanchable petechial rash after experiencing a seizure.
  • The rash emerged during transport to the emergency department and resolved within seven days.
  • Initial investigations, including imaging and basic laboratory tests, were unremarkable except for elevated postictal markers.

Findings:

  • The patient's rash was directly linked to the generalized epileptic seizures.
  • No alternative etiology for the petechial rash was identified.
  • Resolution of the rash correlated with the control of seizure activity.

Implications:

  • Postictal cutaneous manifestations, such as petechiae, can serve as diagnostic indicators for seizures.
  • Recognizing these skin changes can prevent unnecessary diagnostic investigations.
  • Understanding the pathophysiology, potentially involving hemodynamic shifts and neurogenic inflammation, can enhance epilepsy care management.