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Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer

Yan Wang1,2,3,4, Liwei Zhao5,6, Zhen Zhang1,2,3,4

  • 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Oncoimmunology
|October 21, 2024
PubMed

Keywords:
Cancer immunotherapyFc receptorImmune checkpoint inhibitorImmunogenic cell deathTotal neoadjuvant therapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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