Changes in Prevalence and Phenotype of Hypertension in Children Suspected of Hypertension Using the 2022 American

Norrarath Nimkarn1, Kwanchai Pirojsakul1, Songkiat Chantarogh1

  • 1Mahidol University, Bangkok, Thailand.

Global Pediatric Health
|October 21, 2024
PubMed

Insights

The 2022 American Heart Association (AHA) guidelines for hypertension (HT) diagnosis in children increased HT prevalence from 48% to 65%. Taller children were more likely to be diagnosed with HT, with some showing left ventricular hypertrophy (LVH).

Area of Science:

  • Pediatrics
  • Cardiology
  • Hypertension Research

Background:

  • The American Heart Association (AHA) updated hypertension (HT) diagnostic guidelines in 2022.
  • Ambulatory blood pressure monitoring (ABPM) is crucial for diagnosing HT in children.
  • Previous guidelines (2014) may have underestimated HT prevalence in pediatric populations.

Purpose of the Study:

  • To assess the impact of the 2022 AHA hypertension guidelines on HT prevalence in children.
  • To evaluate changes in the phenotype of hypertension in children following the new guidelines.
  • To identify factors associated with HT diagnosis escalation in pediatric patients.

Main Methods:

  • A cohort of 100 children (aged 6-20) suspected of hypertension underwent 24-hour ABPM.
  • Patients were categorized into escalated, de-escalated, or unchanged HT diagnosis groups based on guideline changes.
  • Demographic data were compared, and logistic regression identified factors linked to HT diagnosis escalation.

Main Results:

  • Hypertension prevalence increased from 48% (2014 AHA guidelines) to 65% (2022 AHA guidelines).
  • Children with escalated HT diagnoses were more likely to be male, older, and taller.
  • Taller height was the sole significant factor associated with HT diagnosis escalation (OR 1.09, P=0.04).
  • Left ventricular hypertrophy (LVH) was detected in 83.3% of escalated patients with available echocardiograms.

Conclusions:

  • The 2022 AHA guidelines lead to increased detection of hypertension in children.
  • A significant proportion (nearly 30%) of children with escalated diagnoses showed LVH.
  • These findings support the utility of the 2022 AHA guidelines for early identification of pediatric cardiovascular risk.
Abstract

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