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Changes in Prevalence and Phenotype of Hypertension in Children Suspected of Hypertension Using the 2022 American
Norrarath Nimkarn1, Kwanchai Pirojsakul1, Songkiat Chantarogh1
1Mahidol University, Bangkok, Thailand.
Insights
The 2022 American Heart Association (AHA) guidelines for hypertension (HT) diagnosis in children increased HT prevalence from 48% to 65%. Taller children were more likely to be diagnosed with HT, with some showing left ventricular hypertrophy (LVH).
Area of Science:
- Pediatrics
- Cardiology
- Hypertension Research
Background:
- The American Heart Association (AHA) updated hypertension (HT) diagnostic guidelines in 2022.
- Ambulatory blood pressure monitoring (ABPM) is crucial for diagnosing HT in children.
- Previous guidelines (2014) may have underestimated HT prevalence in pediatric populations.
Purpose of the Study:
- To assess the impact of the 2022 AHA hypertension guidelines on HT prevalence in children.
- To evaluate changes in the phenotype of hypertension in children following the new guidelines.
- To identify factors associated with HT diagnosis escalation in pediatric patients.
Main Methods:
- A cohort of 100 children (aged 6-20) suspected of hypertension underwent 24-hour ABPM.
- Patients were categorized into escalated, de-escalated, or unchanged HT diagnosis groups based on guideline changes.
- Demographic data were compared, and logistic regression identified factors linked to HT diagnosis escalation.
Main Results:
- Hypertension prevalence increased from 48% (2014 AHA guidelines) to 65% (2022 AHA guidelines).
- Children with escalated HT diagnoses were more likely to be male, older, and taller.
- Taller height was the sole significant factor associated with HT diagnosis escalation (OR 1.09, P=0.04).
- Left ventricular hypertrophy (LVH) was detected in 83.3% of escalated patients with available echocardiograms.
Conclusions:
- The 2022 AHA guidelines lead to increased detection of hypertension in children.
- A significant proportion (nearly 30%) of children with escalated diagnoses showed LVH.
- These findings support the utility of the 2022 AHA guidelines for early identification of pediatric cardiovascular risk.
Objective:
The American Heart Association (AHA) launched the 2022 guidelines for the diagnosis of hypertension (HT) by ambulatory blood pressure monitoring (ABPM). The present study aimed to evaluate the impacts of the 2022 AHA guidelines on the changes in the prevalence and phenotype of HT in children suspected of HT.
Methods:
Consecutive 100 children aged 6 to 20 suspected of HT who underwent 24-hour ABPM were recruited. The patients were separated into 3 groups: escalated, de-escalated, and unchanged. Demographic data were compared between the 3 groups. Logistic regression analysis was performed to evaluate the factors associated with the escalation in the diagnosis of HT.
Results:
The present study revealed that the prevalence of HT, including sustained and masked HT, increased from 48% by the 2014 AHA guidelines to 65% by the 2022 AHA guidelines. Patients in the escalated group tended to have a higher proportion of male gender, with an older age and a taller height compared to those in the de-escalated group. Multivariate analysis showed that height was the only factor associated with the escalation in the diagnosis of HT [OR 1.09 (1.01-1.19), P-value .04]. Five out of 6 (83.3%) patients in the escalated group with available echocardiographic results had left ventricular hypertrophy (LVH).
Conclusion:
Using the 2022 AHA guidelines resulted in more detection of patients with HT, and almost 30% of the escalated group had LVH. This finding supports using the 2022 AHA guidelines to detect children at risk of developing cardiovascular diseases early.
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Physiological Factors:

