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Statin Use and the Progression of Coronary Artery Calcification in CKD: Findings From the KNOW-CKD Study

Jihyun Yang1, Kyu-Beck Lee1, Hyang Kim1

  • 1Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Kidney International Reports
|October 21, 2024
PubMed

Insights

Statin use is linked to faster coronary artery calcification (CAC) progression in Korean adults with predialysis chronic kidney disease (CKD). This finding suggests statins may paradoxically accelerate CAC in this vulnerable patient group.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Statins are widely used to reduce cardiovascular disease (CVD) risk.
  • Previous research indicates statin use is associated with coronary artery calcification (CAC) progression in patients with preserved renal function or on dialysis.
  • The relationship between statin use and CAC progression in predialysis chronic kidney disease (CKD) remains largely unknown.

Purpose of the Study:

  • To investigate the association between statin use and the progression of coronary artery calcification (CAC) in Korean adults with predialysis chronic kidney disease (CKD).
  • To characterize the relationship between statin use and CAC progression within this specific patient cohort.

Main Methods:

  • Analysis of 1177 participants from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD).
  • Coronary artery calcium score (CACS) assessed via cardiac computed tomography at baseline and after 4 years.
  • CAC progression defined using the Sevrukov method; statin users defined as those using statins for ≥50% of the follow-up period.

Main Results:

  • After 4 years, 52.0% of participants showed CAC progression.
  • CAC progression was significantly more frequent in statin users (58.3%) compared to non-users (41.7%) (P < 0.001).
  • Multivariate-adjusted odds ratio for CAC progression was 1.78 (1.26-2.50) in statin users versus non-users.

Conclusions:

  • Statin use is significantly and independently associated with accelerated CAC progression in Korean patients with predialysis CKD.
  • Further research is necessary to understand the prognostic implications of statin-associated CAC progression in this population.
Abstract

Keywords:
chronic kidney diseasecoronary artery calcificationstatin

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