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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Patient Selection for Deep Brain Stimulation for Pantothenate Kinase-Associated Neurodegeneration.
Jason L Chan1,2, Ashley E Rawls1,2, Joshua K Wong1,2
1Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.
Deep brain stimulation (DBS) improved generalized dystonia and gait in a patient with pantothenate kinase-associated neurodegeneration (PKAN). This benefit persisted for over a year, offering hope for managing this rare neurodegenerative disorder.
Area of Science:
- Neuroscience
- Neurology
- Medical Technology
Background:
- Pantothenate kinase-associated neurodegeneration (PKAN) is a rare neurodegenerative disorder.
- Generalized dystonia and gait impairment are common, often medication-refractory symptoms in PKAN.
- Deep brain stimulation (DBS) is an established treatment for dystonia, but its efficacy in PKAN is variable.
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