Two Squaramide-Based Fluorescent Probes for Cu2+ and Cd2
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Updated: Jun 9, 2025

Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
Yuanwei Li1,2, Hongxu Wang1,2, Qian Tao1,2
1College of Chemistry and Chemical Engineering of China West Normal University, Nanchong, 637000, China.
Abstract:
The development of potential toxic metal ion probes is of great significance in the field of environmental detection. Herein, two squaramide ligands (2a, 2b) were constructed by combining the characteristics of squaric acid and imine groups. 2a and 2b can recognize Cu2+ and Cd2+, with LOD of 1.26 × 10-8 M and 2.04 × 10-8 M, respectively, and have the advantages of fast response and wide pH range. The binding ratio and binding mode of the probe and the target ion were determined by Job's plot, ESI-MS, and 1H NMR.

