Related Experiment Video

Updated: Jun 9, 2025

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.5K

Maternal Immunization

Hye-Kyung Cho1, Collrane Frivold2,3, Helen Y Chu2

  • 1Department of Pediatrics, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.

The Journal of Infectious Diseases
|October 21, 2024
PubMed

Pregnant individuals and infants are at risk from vaccine-preventable diseases like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza. Maternal vaccination during pregnancy can protect both the mother and child. Recent progress in developing these vaccines is notable, but vaccine hesitancy and the exclusion of pregnant individuals from clinical trials limit their use. Maternal immunization safeguards mothers from severe illness and adverse pregnancy outcomes while providing infants with antibodies through the placenta and breast milk. Inactivated vaccines are generally effective and safe during pregnancy. Limited safety and efficacy data due to exclusion from trials hinder vaccine uptake; however, vaccines like tetanus-diphtheria-acellular pertussis (Tdap), influenza, and SARS-CoV-2 have proven effective, and are recommended vaccines during pregnancy. New vaccines for group B Streptococcus (GBS) and cytomegalovirus are in development, with the GBS vaccine being the most advanced. Combating vaccine hesitancy through strong health care provider recommendations is vital to enhance uptake and protect pregnant individuals and their infants.

Keywords:
immunizationinfantspregnancysafetyvaccine

More Related Videos

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.3K
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
291
Vaccinations01:51

Vaccinations

Overview
44.1K
Active versus Passive Immunity01:31

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
582
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
545
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1