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Updated: Jun 9, 2025

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
Published on: August 9, 2019
Finding NEMO in the thymus
Juan Moises Ocampo-Godinez1, Alexandra Y Kreins1,2
1Infection Immunity and Inflammation Research and Teaching Department, University College London Institute of Child Health, London, UK.
Abstract:
Rosain et al. (https://doi.org/10.1084/jem.20231152) describe the association between anti-type I interferon autoantibodies and severe viral infections in patients with incontinentia pigmenti and heterozygous loss-of-function NEMO variants, suggesting a role for canonical NF-κB signaling in immune tolerance. The mechanisms behind this selective autoimmunity remain unclear.

