Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiation: Applications01:17

Radiation: Applications

1.8K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.8K
Positron Emission Tomography01:29

Positron Emission Tomography

6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A standardized workflow for the development and manufacturing of tissue-equivalent anthropomorphic phantoms for radiotherapy using 3D-printing.

Physics in medicine and biology·2026
Same author

Assessing dosimetric uncertainties in Papillon+ contact x-ray brachytherapy for rectal cancer: impact of beam quality and tumour geometry.

Physics in medicine and biology·2026
Same author

Evaluation of proton range differences in photon-counting and dual-energy computed tomography across imaging doses and anthropomorphic phantom sizes.

Physics in medicine and biology·2026
Same author

Large language models for structured cardiovascular data extraction: a foundation for scalable research and clinical applications.

European heart journal. Digital health·2026
Same author

Evaluation of radiological properties and anisotropy with air channels analysis in 3D-printed flexible lung-mimicking materials for radiotherapy.

Physics in medicine and biology·2026
Same author

Probabilistic proton treatment planning: a novel approach for optimizing underdosage and overdosage probabilities of target and organ structures.

Physics in medicine and biology·2026
Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026
Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026
Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026
Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K

A simulation framework for preclinical proton irradiation workflow.

Justin Malimban1, Felix Ludwig1, Danny Lathouwers2

  • 1Department of Radiation Oncology and Particle Therapy Research Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Physics in Medicine and Biology
|October 21, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a simulation framework for optimizing proton therapy experiments in small animals. The findings suggest single-energy CT (SECT) is adequate for proton treatment planning, reducing the need for animal testing.

Keywords:
Monte Carlodual-energy CTmicro-CT simulationpreclinical proton dose calculationssingle-energy CTstopping power

More Related Videos

Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.7K

Related Experiment Videos

Last Updated: May 5, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.3K
Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.7K

Area of Science:

  • Medical Physics
  • Preclinical Research
  • Radiation Oncology

Background:

  • Proton beamlines integrated with X-ray imaging enable image-guided Bragg peak irradiations in small animals.
  • Targeting small animal tumors and normal tissue requires precise experimental design, which is challenging due to size and location constraints.
  • A simulation framework is crucial for optimizing beamlines, imaging protocols, and experimental designs.

Purpose of the Study:

  • To develop and demonstrate a simulation framework for optimizing preclinical proton therapy experiments.
  • To evaluate the accuracy of micro-CT imaging protocols for proton stopping power ratio (SPR) estimation in small animals.
  • To assess the impact of different CT imaging protocols on proton dose distribution calculations.

Main Methods:

  • Modified the fastCAT toolkit with Monte Carlo (MC)-calculated data for simulating micro-CT scans.
  • Validated fastCAT simulations against full MC TOPAS CT simulations.
  • Generated simulated CT images using single-energy CT (SECT) and dual-energy CT (DECT) protocols for a digital mouse phantom.

Main Results:

  • CT number agreement within 11 HU between fastCAT and TOPAS, with discrepancies attributed to beam hardening.
  • Root mean square deviation in SPR was 3.7% for SECT (90 kV/Cu) and 1.0% for DECT (50 kV/Al-90 kV/Al).
  • Dose distributions showed minimal range shifts (<0.1 mm) and high gamma pass rates (>99%) for both SECT and DECT, indicating no substantial dosimetric differences.

Conclusions:

  • The developed simulation framework aids in optimizing experimental configurations without using animals or beam time.
  • Single-energy CT (SECT) is sufficient for proton treatment planning in small animal studies.
  • The framework facilitates efficient development and validation of preclinical proton therapy research setups.