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Composition of fresh frozen plasma
Critical Care Medicine
|February 1, 1986
Summary
Fresh frozen plasma (FFP) is hyperosmolar and hyperglycemic, with high sodium and low chloride levels. Its lower albumin content may reduce its effectiveness as a volume expander compared to other solutions.
Area of Science:
- Biochemistry
- Hematology
- Clinical Chemistry
Background:
- Fresh frozen plasma (FFP) is a common blood product used for volume expansion and treating coagulopathies.
- Understanding the biochemical composition of FFP is crucial for optimizing its clinical application.
Purpose of the Study:
- To analyze the biochemical composition of fresh frozen plasma.
- To evaluate FFP's osmolality, glucose, electrolyte, and protein content.
- To compare FFP's potential as a volume expander with other albumin-containing solutions.
Main Methods:
- Analysis of 35 fresh frozen plasma samples.
- Measurement of glucose, sodium, chloride, potassium, bicarbonate, and protein concentrations.
- Calculation of osmolality based on measured components.
Main Results:
- Mean concentrations: glucose 535 mg/dl, sodium 172 mEq/L, chloride 73 mEq/L, potassium 3.5 mEq/L, bicarbonate 15 mEq/L, protein 5.5 g/dl.
- Albumin content was 60% of total protein.
- FFP was identified as hyperosmolar, hyperglycemic, hypernatremic, and hypochloremic.
Conclusions:
- FFP exhibits a hyperosmolar and hyperglycemic profile with significant sodium and chloride imbalances.
- Lower albumin content in FFP may limit its efficacy as a volume expander.
- Clinical use of FFP should consider its biochemical properties and potential limitations.