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Updated: May 7, 2026

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A Novel In Vitro Model of Blast Traumatic Brain Injury
Published on: December 21, 2018
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Numerical Investigation of the Blast-Induced Injuries Using an Open-Source Detailed Human Model
Alberto Morena1, Lorenzo Peroni1, Martina Scapin1
1Politecnico di Torino, Turin, Italy.
Summary
This study validates the Total Human Model for Safety (THUMS) for predicting blast injuries. The open-source human model accurately reproduces primary blast traumas, aiding standardized computational frameworks for explosion response.
Area of Science:
- Biomechanics
- Computational modeling
- Trauma research
Background:
- Explosions pose significant risks in both military and civilian settings.
- Developing standardized computational frameworks for blast injury prediction remains a challenge.
- Existing numerical models lack a unified approach for simulating blast impacts.
Purpose of the Study:
- To assess the predictive capability of the Total Human Model for Safety (THUMS) for blast-induced traumas.
- To evaluate the suitability of the publicly available THUMS pedestrian model for establishing a common modeling framework.
- To investigate the response of vital organs within the THUMS model under various blast scenarios.
Main Methods:
- Simulating blast scenarios in both free-field and partially confined environments.
- Exposing the THUMS human model to diverse blast conditions.
- Analyzing the trauma patterns and responses of internal organs within the THUMS model.
Main Results:
- THUMS demonstrated consistency between simulated internal organ trauma patterns and existing experimental data.
- The model's predictions aligned with established injury thresholds for blast effects.
- The THUMS model proved effective in reproducing primary blast-related injuries.
Conclusions:
- The open-source THUMS human model is validated for simulating primary blast injuries.
- This research supports the development of standardized numerical simulations for human response to explosions.
- THUMS offers a promising tool for enhancing safety planning and response strategies for blast events.

