Development of Mathematical Function Control-Based 3D Printed Tablets and Effect on Drug Release
Honghe Wang1, Indrajeet Karnik1, Prateek Uttreja1
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.
Pharmaceutical Research
|October 21, 2024
Summary
3D printed tablet surface geometry precisely controls drug release rates. Mathematical functions adjusted tablet shapes, demonstrating a direct correlation between surface curvature and dissolution speed for personalized medicine applications.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Biomedical Engineering
Background:
- 3D printing offers potential for personalized drug delivery but faces challenges in controlling drug release.
- Precise control over drug release profiles is crucial for optimizing therapeutic efficacy and patient compliance.
Purpose of the Study:
- To apply surface equations for constructing 3D printed tablet models.
- To adjust functional parameters and create multiple tablet models.
- To correlate model parameters with in vitro drug release behavior.
Main Methods:
- Developed 3D-printed tablets using fused deposition modeling (FDM) and hot-melt extrusion (HME).
- Controlled tablet surface geometries with mathematical functions to modulate drug release.
- Produced tablets (T1-T5) by varying parabolic surface depth to assess curvature impact on dissolution.
Main Results:
- The T5 formulation (greatest curvature) showed the fastest drug release (complete within 4 hours).
- T1 and T2 tablets exhibited slower release profiles (approximately 6 hours).
- Confirmed a correlation between surface area and drug release rate, aligning with the Noyes-Whitney equation.
Conclusions:
- Precise control of tablet surface geometry effectively tailored drug release profiles.
- This approach enhances patient compliance and treatment efficacy.
- Offers a reproducible and adaptable platform for optimizing drug delivery in personalized medicine.
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