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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

121
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Development of Mathematical Function Control-Based 3D Printed Tablets and Effect on Drug Release.

Honghe Wang1, Indrajeet Karnik1, Prateek Uttreja1

  • 1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.

Pharmaceutical Research
|October 21, 2024
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Summary

3D printed tablet surface geometry precisely controls drug release rates. Mathematical functions adjusted tablet shapes, demonstrating a direct correlation between surface curvature and dissolution speed for personalized medicine applications.

Keywords:
fused deposition modelinghot-melt extrusionprediction modelingsurface equationsthree-dimensional printing

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Biomedical Engineering

Background:

  • 3D printing offers potential for personalized drug delivery but faces challenges in controlling drug release.
  • Precise control over drug release profiles is crucial for optimizing therapeutic efficacy and patient compliance.

Purpose of the Study:

  • To apply surface equations for constructing 3D printed tablet models.
  • To adjust functional parameters and create multiple tablet models.
  • To correlate model parameters with in vitro drug release behavior.

Main Methods:

  • Developed 3D-printed tablets using fused deposition modeling (FDM) and hot-melt extrusion (HME).
  • Controlled tablet surface geometries with mathematical functions to modulate drug release.
  • Produced tablets (T1-T5) by varying parabolic surface depth to assess curvature impact on dissolution.

Main Results:

  • The T5 formulation (greatest curvature) showed the fastest drug release (complete within 4 hours).
  • T1 and T2 tablets exhibited slower release profiles (approximately 6 hours).
  • Confirmed a correlation between surface area and drug release rate, aligning with the Noyes-Whitney equation.

Conclusions:

  • Precise control of tablet surface geometry effectively tailored drug release profiles.
  • This approach enhances patient compliance and treatment efficacy.
  • Offers a reproducible and adaptable platform for optimizing drug delivery in personalized medicine.