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Updated: Jun 9, 2025
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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Cell senescence in cardiometabolic diseases
1Endocrinology, Diabetes and Nutrition, UCLouvain, Brussels, Belgium. mandy.grootaert@uclouvain.be.
Npj Aging
|October 21, 2024
Summary
Cellular senescence, a state of irreversible cell cycle arrest, contributes to age-related heart and metabolic diseases. Targeting senescent cells offers potential therapeutic benefits for these conditions.
Area of Science:
- Gerontology and cardiovascular medicine.
- Cellular biology and pathology.
Background:
- Cellular senescence is linked to age-related diseases like atherosclerosis, heart failure, and metabolic syndrome.
- Understanding senescent cells and their regulators is crucial for disease intervention.
Purpose of the Study:
- To review the characteristics of senescent cells and their regulators.
- To summarize metabolic stressors inducing senescence.
- To discuss senescence's role in cardiometabolic diseases and anti-senescence therapy potential.
Main Methods:
- Literature review of cellular senescence.
- Analysis of endogenous regulators and metabolic stressors.
- Examination of evidence in cardiometabolic disease progression.
Main Results:
- Senescent cells exhibit specific characteristics and are regulated by endogenous factors.
- Metabolic stressors are identified as inducers of cellular senescence.
- Evidence supports the involvement of senescence in cardiometabolic disease pathogenesis.
Conclusions:
- Cellular senescence plays a significant role in age-related cardiometabolic diseases.
- Targeting senescent cells presents a promising therapeutic strategy for these conditions.
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