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Modeling and evaluation of ivermectin release kinetics from 3D-printed tablets
Cintia Alejandra Briones Nieva1, Juan Pablo Real2, Santiago Nicolás Campos1
1Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta - Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Bolivia 5150, Salta, 4400, Argentina.
Therapeutic Delivery
|October 22, 2024
Summary
Geometric dimensions significantly influence 3D-printed tablet drug release kinetics. This study shows 3D printing versatility for creating customized drug delivery systems with tailored release profiles.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Drug Delivery
Background:
- 3D printing offers potential for personalized medicine and customized drug dosage forms.
- Controlling drug release profiles is crucial for therapeutic efficacy and patient compliance.
Purpose of the Study:
- To investigate the impact of geometric dimensions on the drug release kinetics of 3D-printed tablets.
- To evaluate the suitability of a Gelucire 50/13 based ink for printing ivermectin-loaded tablets.
Main Methods:
- Preparation and physicochemical characterization of a Gelucire 50/13 based ink.
- 3D printing of ivermectin-loaded tablets with varied geometric dimensions.
- In vitro dissolution testing to assess drug release profiles.
Main Results:
- The ink was suitable for 3D printing at temperatures above 46°C.
- Ivermectin crystallinity changed without chemical interaction with the polymer matrix.
- Tablets with varied sizes exhibited dual release profiles, while thickness-modified tablets showed zero-order kinetics.
Conclusions:
- 3D printing allows for precise control over tablet geometry to achieve specific drug release profiles.
- This technology provides a versatile platform for developing customized drug delivery systems.
- Geometric modifications are a viable strategy for tailoring drug release kinetics.
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