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Crohn's disease-associated keratopathy: A case report.
Ji Ho Kim1, Yeo Kyoung Won1, Tae-Young Chung1,2
1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
American Journal of Ophthalmology Case Reports
|October 22, 2024
Summary
This case study shows Crohn's disease-associated keratopathy worsening with increased fecal calprotectin levels, indicating active inflammation. Corneal healing occurred as inflammation markers decreased, suggesting a link between gut and eye health.
Area of Science:
- Ophthalmology
- Gastroenterology
- Immunology
Background:
- Crohn's disease is a chronic inflammatory bowel disease.
- Ocular manifestations can occur in Crohn's disease patients.
- Keratopathy, a corneal disease, has been rarely associated with Crohn's disease.
Observation:
- A 29-year-old male with Crohn's disease on adalimumab presented with bilateral keratopathy.
- Ophthalmological findings included epithelial irregularities, corneal opacity, subepithelial infiltration, pannus, and neovascularization.
- Stool calprotectin levels were monitored alongside ocular changes.
Findings:
- Keratopathy severity correlated with elevated fecal calprotectin levels, indicating active intestinal inflammation.
- Corneal neovascularization and infiltration improved as fecal calprotectin levels decreased.
- This suggests a direct relationship between gastrointestinal inflammation and ocular disease activity.
Implications:
- The findings suggest an autoimmune link between Crohn's disease activity and keratopathy.
- Managing gastrointestinal inflammation may be crucial for treating Crohn's disease-associated keratopathy.
- Collaboration between gastroenterology and ophthalmology is important for patient care.
