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Updated: Jun 9, 2025
08:59
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
7.8K
In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals
Matthew Burbank1, Predrag Kukic2, Gladys Ouedraogo1
1L'Oréal Research & Innovation, Aulnay-Sous-Bois, France.
Toxicology and Applied Pharmacology
|October 22, 2024
Summary
A new in vitro pharmacology profiling panel (APPP) assessed 129 cosmetic chemicals. This approach supports cosmetic chemical risk assessment without new animal studies.
Area of Science:
- Toxicology
- Pharmacology
- In vitro assays
Background:
- Traditional animal testing for cosmetic safety is being replaced by new approach methodologies.
- Understanding chemical interactions with biological targets is crucial for predicting systemic toxicity.
Purpose of the Study:
- To develop and validate an in vitro pharmacology profiling panel (APPP) for cosmetic chemicals.
- To assess the utility of the APPP in supporting risk assessments for cosmetic ingredients.
Main Methods:
- Developed an APPP comprising 83 target assays, including pharmaceutical and toxicity-relevant targets.
- Profiled 129 diverse cosmetic chemicals using the APPP.
- Evaluated data consistency and concordance with existing datasets (ToxCast, drug excipients).
Main Results:
- The APPP demonstrated robust internal data consistency and reproducibility.
- The profiling results showed good concordance with established toxicological datasets.
- The study successfully demonstrated the potential of the APPP for cosmetic chemical risk assessment.
Conclusions:
- The developed APPP is a validated tool for in vitro profiling of cosmetic chemicals.
- This methodology offers a viable alternative to animal testing for cosmetic safety evaluations.
- The APPP data can be integrated with other new approach methodologies for comprehensive risk assessment.
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