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Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain

Paul T Gomez1,2, Chase M Carver1,2, Sonia L Rodriguez1,2

  • 1Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.

Npj Aging
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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