Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

70.4K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
70.4K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

61.9K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
61.9K
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

1
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
1
Gene Therapy00:59

Gene Therapy

25.3K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrent Facial Folliculitis Caused by Klebsiella aerogenes Sequence Type 117 in Men who Have Sex with Men.

Emerging infectious diseases·2026
Same author

Evolution of resistance patterns in Enterobacterales according to urinary tract infection diagnosis: implications for empirical therapy in a French emergency department.

BMC infectious diseases·2026
Same author

[Second day of the interdisciplinary group dedicated to phage therapy and biocontrol].

Virologie (Montrouge, France)·2026
Same author

Severity and recurrence of Haemophilus influenzae pneumonia in adults are frequent and associated with distinct pathogenic patterns.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Analytical feasibility of linezolid quantification by LC-MS/MS using dried plasma spot microsampling.

International journal of antimicrobial agents·2026
Same author

New French Guidelines on Subcutaneous Antibiotic Therapy: A Response to Di Bella et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Related Experiment Video

Updated: Jun 9, 2025

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
07:22

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings

Published on: August 19, 2021

2.9K

[Phage therapy: where do we stand?]

Alexandre Bleibtreu1, Sylvain Diamantis2

  • 1Service des maladies infectieuses et tropicales, hôpital La Pitié-Salpêtrière, AP-HP, Paris, France.

La Revue Du Praticien
|October 23, 2024
PubMed
Summary

Bacteriophage (phage) therapy offers a specific alternative to antibiotics for bacterial infections. While promising, its widespread adoption in France faces challenges in production and clinical validation.

Keywords:
Bacteriophages

More Related Videos

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

1.8K
Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
08:46

Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice

Published on: January 26, 2024

1.5K

Related Experiment Videos

Last Updated: Jun 9, 2025

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
07:22

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings

Published on: August 19, 2021

2.9K
Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

1.8K
Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
08:46

Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice

Published on: January 26, 2024

1.5K

Area of Science:

  • Microbiology
  • Virology
  • Pharmacology

Context:

  • Bacteriophages (phages), viruses targeting bacteria, were discovered in the early 20th century.
  • Antibiotics overshadowed phage therapy after initial successes, but antibiotic resistance has spurred its resurgence.
  • Phage therapy is recognized as medicine, yet faces production limitations and requires further clinical trials.

Purpose:

  • To review the current status and challenges of phage therapy in France.
  • To highlight the potential of phage therapy as a specific alternative to broad-spectrum antibiotics.
  • To discuss the need for clinical trials to validate phage therapy efficacy, especially in combination with antibiotics.

Summary:

  • Phage therapy, a treatment using viruses that infect bacteria, is gaining traction due to rising antibiotic resistance.
  • Despite historical success and recent resurgence, phage therapy in France is primarily used on a compassionate basis.
  • Ongoing clinical trials are evaluating phage therapy's efficacy, particularly when combined with antibiotics.

Impact:

  • Phage therapy presents a promising avenue to combat bacterial infections, especially those resistant to antibiotics.
  • Further clinical validation and scaled production are crucial for the routine adoption of phage therapy.
  • France's historical leadership in phage therapy is being challenged, necessitating strategic advancements for future integration.