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Related Concept Videos

Layers of the Heart Wall01:15

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

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Related Experiment Video

Updated: Jun 15, 2026

Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
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HoloPatch: improving intracardiac patch fit through holographically modelled templates.

Matthias Lippert1,2, Gabriella d' Albenzio1,3, Kathrine Rydén Suther4

  • 1Division for Technology and Innovation, The Intervention Centre, Oslo University Hospital, PO Box 4950 Nydalen, 0424 Oslo, Norway.

European Heart Journal. Imaging Methods and Practice
|October 23, 2024
PubMed
Summary

Digital patch templates created using mixed-reality technology closely match surgical materials for structural heart defect repair. This approach may reduce complications associated with ventricular septal defect closure and intracardiac rerouting.

Keywords:
3D printHoloLenscardiothoracic surgerycongenital heart diseasemixed-reality

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Area of Science:

  • Cardiovascular Surgery
  • Medical Device Technology
  • Digital Health

Background:

  • Surgical repair of structural heart defects often uses hand-cut patches.
  • Imperfect patch fit can lead to complications like outflow tract obstruction and residual defects.

Purpose of the Study:

  • To benchmark mixed-reality (MR) and desktop applications for creating digital heart patch templates.
  • To compare digital patches against actual implanted surgical material.

Main Methods:

  • Digital models of implanted patches were created from surgical remnants.
  • Clinical experts generated digital patches using MR and desktop software.
  • Comparison with a digitalized model of the real patch and assessment of residual shunt risk.

Main Results:

  • MR-created digital patches closely matched the size of the actual surgical material.
  • Desktop application patches were significantly smaller than the real patches.
  • Evaluator preferences varied for assessing shunt risk and patch area.

Conclusions:

  • Digital patch templates, particularly those from MR, show promise for accurate preoperative sizing.
  • This technology may help reduce post-operative complications in structural heart defect repair.