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Temperature Distribution on Classical Two Needles IRE Setup Versus a Single Needle Prototype.

Ali Jouni¹, Marco Baragona², Federico Pedersoli³

¹University Hospital RWTH Aachen, Clinic for Diagnostic and Interventional Radiology, Aachen, Germany.

Technology in Cancer Research & Treatment

|October 23, 2024

Summary

This summary is machine-generated.

A new prototype for Irreversible Electroporation (IRE) therapy shows potential for improved liver tumor treatment. This design localizes thermal effects within the tumor, unlike traditional methods, enhancing safety for surrounding tissues.

Keywords:

Expandable electrode FEM IRE IRECT NanoKnife computer aided design computer simulation electroporation finite element method irreversible electroporation minimal invasive therapy single needle electroporation temperature distribution

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Area of Science:

Medical Physics
Oncology
Biomedical Engineering

Background:

Irreversible Electroporation (IRE) is a non-thermal cancer therapy for liver tumors.
Heat generation during IRE necessitates careful analysis to prevent damage to sensitive structures.
Optimizing heat distribution is crucial for maximizing therapeutic effects and minimizing collateral thermal damage.

Purpose of the Study:

To compare the heat distribution of a novel single-needle, multiple-electrode IRE prototype with the standard two-parallel-needle setup.
To evaluate the thermal effects and necrosis patterns generated by different IRE electrode configurations in liver tumor treatment.

Main Methods:

Numerical simulations in COMSOL Multiphysics were used to analyze temperature distribution for both electrode setups.
Investigated temperature levels and distributions at various distances from applicators during IRE treatment.
Compared simulation results with existing in-vivo data for validation.

Main Results:

The prototype generated a higher maximum average temperature (74°C) compared to the two-needle setup (57°C).
Both configurations produced similar thicknesses of coagulation necrosis.
Crucially, the prototype's necrosis was localized within the tumor, whereas the two-needle setup's necrosis extended outside the tumor.

Conclusions:

Heat distribution analysis is vital for designing new IRE electrodes and planning treatments.
The prototype design offers improved localization of thermal effects within the target tumor.
This approach enhances the safety of IRE therapy by minimizing damage to surrounding healthy tissues.