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Association of High-sensitivity C-reactive Protein Level with Obese Normal individuals in North Indian Population
Neeraja Shukla1, Soni Singh, Shraddha Singh
1Department of Physiology, King George Medical University, Lucknow, Uttar Pradesh, India.
Insights
High-sensitivity C-reactive protein (hs-CRP) was not associated with obesity or its related anthropometric measures in a North Indian population. This study found no significant correlation between hs-CRP levels and waist circumference, hip circumference, or waist-to-hip ratio in overweight and obese individuals.
Area of Science:
- Cardiovascular Health
- Obesity Research
- Inflammatory Markers
Background:
- C-reactive protein (CRP) is a key inflammatory marker linked to cardiovascular events.
- Obesity elevates CRP by activating cytokines, increasing heart disease risk.
- Elevated CRP levels independently predict heart disease, stroke, and sudden cardiac death.
Purpose of the Study:
- To investigate the association between high-sensitivity CRP (hs-CRP) and obesity in a North Indian population.
- To evaluate hs-CRP levels in individuals classified as overweight or obese.
Main Methods:
- A cross-sectional study involving 50 overweight or obese individuals (aged 18-50).
- Anthropometric measurements included height, weight, waist circumference (WC), hip circumference, and blood pressure.
- Blood samples were analyzed for hs-CRP using enzyme-linked immunosorbent assay.
Main Results:
- Obese individuals had significantly higher mean WC and lower mean hip circumference compared to overweight individuals.
- The waist-to-hip ratio (WHR) was significantly higher in the obese group.
- No significant correlation was found between hs-CRP and WC, hip circumference, or WHR in overweight and obese participants.
Conclusions:
- hs-CRP levels were not found to be related to obesity in this North Indian cohort.
- No association was identified between hs-CRP and key anthropometric indicators of obesity (WC, hip circumference, WHR).
Background:
One of the major inflammatory markers, C-reactive protein (CRP), is often elevated in people who have had a heart attack, vascular problems, stroke, or sudden cardiac death. Obesity is associated with higher CRP levels because adipose tissue activates cytokines. Obesity and overweight increase the risk of heart disease, as does an elevated CRP level.
Purpose:
The purpose of this study was to evaluate the association of high-sensitivity CRP (hs-CRP) level with obese normal individuals in North Indian population.
Materials And Methods:
This cross-sectional study included 50 individuals between the ages of 18 and 50 years who were overweight or obese. The degree of obesity was determined by anthropometric measurements. The patients' height, weight, waist circumference (WC), hip circumference, and blood pressure were measured. Enzyme-linked immunosorbent assay-based CRP level was determined from the blood.
Results:
The mean WC (cm) was significantly higher in the obese (103.42 ± 9.79) than in the overweight (89.00 ± 8.72). The mean hip circumference (cm) was also significantly smaller in the obese group (99.95 ± 8.07) than in the overweight group (131.29 ± 15.82). The waist-to-hip ratio (WHR) was significantly more in the obese group (88.37%) than in the overweight group (0.00%). WC (cm), hip circumference (cm), WHR, systolic blood pressure (mmHg), and diastolic blood pressure (mmHg) were not significantly correlated with hs-CRP in overweight and obese participants.
Conclusion:
Compared with obesity, hs-CRP was not related to obesity. A relationship between hs-CRP and WC, hip circumference, and WHR was not found.
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