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Published on: March 13, 2011
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[Development of selective method for identifying mebeverine in hair]
P S Vikman1, O L Balabanova2, O Yu Strelova1
1Saint-Petersburg State Chemical and Pharmaceutical University, St. Petersburg, Russia.
Sudebno-Meditsinskaia Ekspertiza
|October 23, 2024
Summary
This study developed a method to detect mebeverine and its metabolites in urine and hair. Hair analysis can distinguish mebeverine use from psychoactive substances, preventing false positives.
Area of Science:
- Forensic toxicology
- Analytical chemistry
- Pharmacology
Context:
- Mebeverine is a medication requiring accurate detection methods.
- Immunochromatographic methods may show cross-reactivity with psychoactive substances.
- Distinguishing mebeverine from similar compounds is crucial for forensic analysis.
Purpose:
- To develop and validate a method for identifying mebeverine and its metabolites in biological samples (urine and hair).
- To address potential cross-reactivity issues with psychoactive substances in preliminary screening.
- To differentiate pharmacological mebeverine use from the use of phenylalklamine-based psychoactive substances.
Summary:
- Mebeverine and its marker metabolites (mebeverine and veratric acids) were identified in urine samples from therapeutic use.
- Enzymatic hydrolysis of hair samples revealed the presence of native mebeverine.
- Hyaluronidase demonstrated effectiveness in isolating mebeverine from hair samples.
Impact:
- The developed method enables accurate identification of mebeverine in biological matrices.
- Hair analysis can reliably differentiate mebeverine use from psychoactive substance abuse.
- This research enhances the specificity of drug testing, particularly in forensic and clinical settings.
