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Related Concept Videos

Fatigue01:21

Fatigue

174
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
174
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

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Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
171
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

896
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Updated: Jun 9, 2025

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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[Fatigue].

Peter Lucassen1, Sonja van Ockenburg2, Rijk Gans2

  • 1Research Institute of Health Sciences, afd. Eerstelijnsgeneeskunde, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|October 23, 2024
PubMed
Summary
This summary is machine-generated.

Many fatigue cases remain unexplained by general practitioners. For persistent fatigue, further investigation including genetic history, blood tests, sleep studies, and specialist referral is crucial for diagnosis and treatment.

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Area of Science:

  • General Practice
  • Internal Medicine
  • Medical Diagnostics

Context:

  • Fatigue is a common but often unexplained symptom presenting to general practitioners.
  • Only about a quarter of fatigue cases have identified somatic or psychosocial causes.
  • A significant majority of patients experience unexplained fatigue, leading to diagnostic challenges.

Purpose:

  • To outline diagnostic strategies for unexplained fatigue in primary care.
  • To emphasize the importance of thorough physical examination and expanded inquiries for prolonged fatigue.
  • To guide general practitioners on when and how to refer patients for specialized evaluation.

Summary:

  • General practitioners often face unexplained fatigue, with somatic causes in 8% and psychosocial in 16% of consulted patients.
  • Thorough physical examination is essential, even with low somatic prevalence.
  • For fatigue exceeding 6 months, expanded history (hereditary diseases), comprehensive blood tests, sleep investigations, and specialist referral are recommended.

Impact:

  • Improved diagnostic yield for complex fatigue cases.
  • Enhanced patient management through timely specialist consultation.
  • Better understanding of prognosis and treatment options for chronic fatigue, including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).