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Updated: Jun 9, 2025

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Diradicaloid-Loaded Polypeptide Nanoparticles for Two-Photon NIR Phototheranostics.

Dejia Chen1,2, Yixuan Xu2, Yating Wang2

  • 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Jinzai Road 96, 230026 Hefei, Anhui, P. R. China.

ACS Applied Materials & Interfaces
|October 23, 2024
PubMed
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This summary is machine-generated.

Researchers developed novel organic stable radicals for enhanced photodynamic therapy (PDT) and imaging. These stable organic radicals offer high fluorescence and improved tumor targeting, paving the way for advanced cancer treatments.

Area of Science:

  • Organic Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Organic small-molecule photosensitizers (PSs) are crucial for tumor photodynamic therapy (PDT).
  • Enhancing PS performance and functionality remains an area of active research.
  • Stable organic radicals exhibit unique electronic transitions and high fluorescence quantum yields.

Purpose of the Study:

  • To synthesize and characterize a novel stable organic radical, Thiele's fluorocarbon derivative diradicaloid TFC-I.
  • To develop amphiphilic polypeptide nanoparticles (P-TI) incorporating TFC-I for improved PDT and bioimaging.
  • To evaluate the efficacy of P-TI in mitochondria-targeted PDT and two-photon fluorescence imaging.

Main Methods:

  • Synthesis of diradicaloid TFC-I with high photoluminescence quantum yield (PLQY).
Keywords:
near-infrared (NIR)photodynamic therapystable organic diradicaloidtumortwo-photon fluorescence imaging

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  • Integration of TFC-I into amphiphilic polypeptide nanoparticles (P-TI) via precursor-doping.
  • Assessment of P-TI's photophysical properties, ROS generation, and performance in vitro and in vivo.

    • Main Results:

    • P-TI exhibited high photostability, aggregation-induced emission, and bright near-infrared fluorescence.
    • Achieved a substantial PLQY of 37% and robust near-infrared two-photon absorption (∼400 GM).
    • Demonstrated superior ROS generation compared to commercial PSs and effective mitochondria-targeted PDT and imaging.

    Conclusions:

    • Stable organic radicals, when integrated into nanoparticles using precursor-doping, offer significant advantages for PDT.
    • P-TI shows great potential for efficient tumor treatment and deep tissue imaging.
    • This approach highlights a promising strategy for developing advanced theranostic agents.