Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function modulates thymic endocrine activity.

N Fabris, E Mocchegiani, S Mariotti

    The Journal of Clinical Endocrinology and Metabolism
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The size of the community rather than its geographical location better defines the risk of iodine deficiency: results of an extensive survey in Southern Italy.

    Journal of endocrinological investigation·2013
    Same author

    Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.

    Journal of endocrinological investigation·2013
    Same author

    The effect of voluntary iodine prophylaxis in a small rural community: the Pescopagano survey 15 years later.

    The Journal of clinical endocrinology and metabolism·2013
    Same author

    Inverse relationship of food and alcohol intake to sleep measures in obesity.

    Nutrition & diabetes·2013
    Same author

    In vivo assessment about the effects of a diet containing iodine-enriched foodstuffs. A pilot study in 30 volunteers.

    Journal of endocrinological investigation·2012
    Same author

    Foreword.

    Journal of endocrinological investigation·2012
    Same journal

    Continuous glucose monitoring-derived time in range is associated with changes in arterial stiffness in type 2 diabetes.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    From Premature Adrenarche to Adult Metabolic Risk and Hyperandrogenism: A Systematic Review and Meta-Analysis.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Open-Label 9-Year Follow-Up Extension Phase 2 Study of Once-Weekly Somatrogon in Children With Growth Hormone Deficiency.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Correction to: "CAHQL: A Patient-Reported Outcome Instrument to Assess Health-Related Quality of Life in Congenital Adrenal Hyperplasia".

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Approach to Personalizing the Treatment of Osteoporosis.

    The Journal of clinical endocrinology and metabolism·2026
    See all related articles

    Thyroid hormones influence thymic endocrine function in humans. Researchers found thymulin (Zn-FTS) levels correlate with thyroid hormone levels, suggesting a link between thyroid status and the immune system.

    Area of Science:

    • Immunology
    • Endocrinology
    • Human Physiology

    Background:

    • The thymus is crucial for T-cell mediated immunity, producing humoral factors.
    • Neuroendocrine networks, particularly thyroid hormones, may modulate thymic function in animals.
    • Human data on the interaction between thyroid hormones and thymic function are lacking.

    Purpose of the Study:

    • To investigate the relationship between thyroid status and thymic endocrine function in humans.
    • To measure circulating thymulin (Zn-FTS) levels in hyperthyroid and hypothyroid patients.
    • To explore the potential role of zinc in mediating thyroid hormone effects on thymulin.

    Main Methods:

    • Measurement of circulating thymulin (Zn-FTS) in hyperthyroid, hypothyroid, and normal subjects.

    Related Experiment Videos

  • Correlation analysis between thymulin levels and serum thyroid hormones (T4, T3).
  • Bioassay modification to assess thymulin activity independent of serum zinc concentrations.

    • Main Results:

    • Hyperthyroid patients exhibited higher thymulin levels than normal subjects.
    • Hypothyroid patients showed lower thymulin levels compared to normal subjects.
    • Circulating thymulin levels significantly correlated with serum T4 and T3 concentrations, with changes reversible upon treatment.

    Conclusions:

    • Human thyroid status significantly modulates thymic endocrine function.
    • The influence of thyroid status on thymulin activity is not mediated by serum zinc concentrations.
    • Further research is needed to establish the clinical relevance of thyroid-mediated immune system modulation.