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CAMs in command: aging brain macrophages fine-tune stroke immune responses

Rodney M Ritzel1, Danye Jiang1, Louise D McCullough1

  • 1Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Trends in Neurosciences
|October 23, 2024
PubMed

Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.

Keywords:
antigen presentationboarder-associated macrophagescell adhesionischemic strokeleukocyte traffickingneuroimmune responses

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