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Sensing and Imaging Agents for Cyclooxygenase Enzyme.

Subba Rao Cheekatla1, Dhiraj P Murale2, Lavanya Gopala1

  • 1Department of Pharmacology, Korea University, 73 Goryeodae-ro, Seongbuk-gu, Seoul, 02841, South Korea.

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New fluorescent probes targeting COX-2 enzymes offer precise cancer imaging and diagnosis. These tools aid in visualizing tumors and inflamed tissues for better cancer research and non-invasive monitoring.

Keywords:
CancerCelecoxibCyclooxygenaseFluorescent probesIndomethacinMolecular imaging

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Area of Science:

  • Biomedical Engineering
  • Molecular Imaging
  • Cancer Diagnostics

Background:

  • Accurate targeting of cancer cells and intracellular activities is vital for early cancer diagnosis and treatment research.
  • Cyclooxygenase-2 (COX-2) is a significant biomarker in cancer, particularly for identifying cancer stem cells and inflamed tissues.

Purpose of the Study:

  • To develop and evaluate COX-2-specific fluorescent probes for enhanced cancer imaging and diagnosis.
  • To investigate the potential of these probes for visualizing tumor and inflamed tissues with high selectivity.

Main Methods:

  • Design and synthesis of fluorescent probes based on indomethacin (IMC), celecoxib, rofecoxib, and CoxFluor derivatives.
  • In vitro and in vivo experiments utilizing mouse models and human tissue samples to assess probe performance.
  • Evaluation of probe selectivity and fluorescence enhancement upon binding to COX-2 enzymes.

Main Results:

  • Probes demonstrated high selectivity and specific fluorescence enhancement upon binding to COX-2.
  • Successful visualization of tumor and inflamed tissues in both in vitro and in vivo models.
  • Efficacy confirmed for detailed imaging in clinical and research applications.

Conclusions:

  • COX-2-specific fluorescent probes represent a significant advancement in non-invasive cancer imaging and diagnosis.
  • These probes facilitate precise visualization and monitoring of cancer-related activities.
  • The developed probes hold great potential for improving early cancer detection and therapeutic strategies.