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Updated: Jun 9, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Drug induced sleep endoscopy and simultaneous polysomnography to predict the effectiveness of mandibular advancement
Ottavio Piccin1,2, Irene Pelligra3, Giulio Alessandri Bonetti4
1Centre for Medical Sciences, University of Trento, Trento, Italy. ottavio.piccin@unitn.it.
Purposes:
To evaluate whether mandibular advancement device therapy is recommended in patients affected by obstructive sleep apnea.
Methods:
In order to predict oral appliances therapy response, drug induced sleep endoscopy with cardio-respiratory polygraphy and mandibular advancement device simulator was carried out. Patients in which upper airway obstruction was resolved on all levels and AHI was normalized (< 5/h), were referred for oral appliance therapy. At 5 months follow up, a cardio-respiratory polygraphy with MAD was performed.
Results:
36 patients who have evidence of resolution of UA collapse and AHI below 5 events per hour, were referred for MAD therapy. At follow up, the mean AHI decreased from 29.1 ± 13.1 to 3.3/h ± 1.9 (p < 0.001). All the patients were responders.
Conclusion:
Combining the evaluation of drug induced sleep endoscopy and cardio-respiratory polygraphy data simultaneously during mandibular protrusion, has the potential to be a useful tool for prediction of MAD therapy response.
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