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Kidney complications in children with bronchopulmonary dysplasia

Samantha W Wallace1, Erica R Geers2, Jason Z Niehaus3

  • 1Pediatric and Adolescent Comparative Effectiveness Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. samwwall@iu.edu.

Pediatric Research
|October 24, 2024
PubMed

Insights

Children with bronchopulmonary dysplasia (BPD) experience high rates of acute kidney injury (AKI) and chronic kidney disease (CKD). Close monitoring for kidney complications is crucial for these children.

Area of Science:

  • Pediatric Nephrology
  • Neonatology
  • Pulmonology

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in infants.
  • Kidney outcomes in children with BPD are not well understood.
  • This study investigates kidney complications in a BPD cohort.

Purpose of the Study:

  • To describe short-term and long-term kidney outcomes in children with BPD.
  • To assess the prevalence of acute kidney injury (AKI) and chronic kidney disease (CKD) in this population.

Main Methods:

  • Retrospective cohort study of children with BPD born between 2010-2020.
  • Assessed AKI using neonatal KDIGO criteria.
  • Evaluated long-term outcomes including CKD (eGFR < 90 mL/min/1.73 m²), albuminuria, and hypertension.

Main Results:

  • 38.8% of 797 children experienced AKI during NICU admission.
  • 32.0% of 510 patients with long-term data had CKD by a median age of 2.2 years.
  • Abnormal eGFR (31.7%), proteinuria (12.5%), and hypertension (15.2%) were observed.

Conclusions:

  • Children with BPD exhibit high frequencies of AKI and CKD.
  • Kidney outcomes in BPD patients require increased attention and monitoring.
  • Findings suggest BPD is associated with significant early childhood kidney complications.
Abstract

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