Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

70.4K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
70.4K
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

2
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
2
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Bacterial Signaling01:30

Bacterial Signaling

31.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.5K
The Central Dogma01:20

The Central Dogma

20.7K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
20.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exon inclusion signatures enable accurate estimation of splicing factor activity.

Nature communications·2026
Same author

Sources of essential lipids for Mycoplasma pneumoniae via P116 to target liver and atherosclerotic lesions.

Nature communications·2025
Same author

Using single-cell perturbation screens to decode the regulatory architecture of splicing factor programs.

Nucleic acids research·2025
Same author

Quantitative essentiality in a reduced genome: a functional, regulatory and structural fitness map.

Molecular systems biology·2025
Same author

Predicting interacting hotspots for nanobodies' binding using triplets of residues.

Protein science : a publication of the Protein Society·2025
Same author

FoldX force field revisited, an improved version.

Bioinformatics (Oxford, England)·2025

Related Experiment Video

Updated: Jun 9, 2025

Bioluminescent Bacterial Imaging In Vivo
05:06

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

15.3K

Bacterial live therapeutics for human diseases.

Elisabet Frutos-Grilo1, Yamile Ana1, Javier Gonzalez-de Miguel1,2

  • 1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Molecular Systems Biology
|October 24, 2024
PubMed
Summary

Live biotherapeutic products (LBPs), particularly bacteria-based therapies, show promise for treating diseases by modulating the immune system and delivering biological products. This review covers recent preclinical and clinical trials of these advanced bacterial therapies.

Keywords:
Gut-Body AxisLive Therapeutic ProductsMicrobiotaOn-Site DeliveryPathogenic Bacteria

More Related Videos

Live-Cell Imaging of the Life Cycle of Bacterial Predator Bdellovibrio bacteriovorus using Time-Lapse Fluorescence Microscopy
08:56

Live-Cell Imaging of the Life Cycle of Bacterial Predator Bdellovibrio bacteriovorus using Time-Lapse Fluorescence Microscopy

Published on: May 8, 2020

8.1K
High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
09:09

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity

Published on: November 16, 2016

7.9K

Related Experiment Videos

Last Updated: Jun 9, 2025

Bioluminescent Bacterial Imaging In Vivo
05:06

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

15.3K
Live-Cell Imaging of the Life Cycle of Bacterial Predator Bdellovibrio bacteriovorus using Time-Lapse Fluorescence Microscopy
08:56

Live-Cell Imaging of the Life Cycle of Bacterial Predator Bdellovibrio bacteriovorus using Time-Lapse Fluorescence Microscopy

Published on: May 8, 2020

8.1K
High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
09:09

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity

Published on: November 16, 2016

7.9K

Area of Science:

  • Synthetic and systems biology
  • Microbiology
  • Immunology

Background:

  • The genomic revolution accelerates progress in live biotherapeutic products (LBPs) for disease treatment.
  • Bacteria-based therapies are a promising class of LBPs due to their colonization and immunomodulatory capabilities.
  • LBPs encompass engineered pathogens and beneficial microbiota for therapeutic applications.

Purpose of the Study:

  • To review recent advancements in preclinical and clinical trials of bacteria-based LBPs.
  • To highlight the therapeutic strategies employed by bacteria-based LBPs.
  • To discuss the potential of bacteria-based therapies in treating human diseases.

Main Methods:

  • Literature review of recent preclinical and clinical studies on bacteria-based LBPs.
  • Analysis of on-site and long-reaching therapeutic strategies.
  • Synthesis of findings on immune modulation and microbial balance.

Main Results:

  • Bacteria-based LBPs demonstrate potential in targeting specific diseases and promoting homeostasis.
  • Both engineered pathogens and commensal bacteria are being explored for therapeutic use.
  • Advancements in preclinical and clinical trials show promising results for various applications.

Conclusions:

  • Bacteria-based LBPs represent a rapidly advancing field with significant therapeutic potential.
  • Further research and clinical trials are crucial to fully realize the benefits of these therapies.
  • Targeted application and understanding of host-microbe interactions are key to successful LBP development.