Association between venous leg ulcers and knee osteoarthritis: A Mendelian randomization study
Deyi Pan1, Runqiao Yang2, Yalan Zhang3
1Department of emergency, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Summary
This study found no significant genetic link between venous leg ulcers (VLUs) and knee osteoarthritis (KOA). Mendelian randomization analysis confirmed no causal relationship in either direction between these conditions.
Area of Science:
- Genetics
- Epidemiology
- Orthopedics
Background:
- Venous leg ulcers (VLUs) and knee osteoarthritis (KOA) are common conditions.
- Understanding potential etiological links between VLUs and KOA is important for patient care.
Purpose of the Study:
- To investigate the potential causal relationship between venous leg ulcers and knee osteoarthritis using a bidirectional Mendelian randomization approach.
Main Methods:
- Utilized two-sample, bidirectional Mendelian randomization (MR) analysis with publicly available genome-wide association study summary data.
- Employed various MR methods including inverse variance weighted (IVW), MR Egger, weighted median, and weighted mode.
- Filtered single-nucleotide polymorphisms (SNPs) to ensure robust genetic association analysis.
Main Results:
- The inverse variance weighted (IVW) analysis showed no significant genetic association between VLUs and KOA (p=0.658).
- Consistent findings were observed across weighted median (p=0.751), MR Egger (p=0.513), and weighted mode (p=0.456) analyses.
- Reverse causality analysis also indicated no significant genetic relationship between KOA and VLUs.
Conclusions:
- The Mendelian randomization study provides no evidence for a causal relationship between venous leg ulcers and knee osteoarthritis.
- Similarly, no evidence supports a reverse causal relationship from knee osteoarthritis to venous leg ulcers.
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