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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Deficient Mismatch Repair Represents a Distinct Molecular Feature of Early-Onset Colorectal Cancer in Chinese
Deng Tang1, Zhigang Mao2, Siqi Lan1
1West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.
International Journal of Cancer
|August 1, 2026
Summary
Early-onset colorectal cancer (EOCRC) in China presents with more aggressive features and a higher rate of deficient mismatch repair (dMMR). Routine MMR testing is recommended for young patients diagnosed with EOCRC.
Area of Science:
- Oncology
- Gastroenterology
- Molecular Biology
Background:
- Early-onset colorectal cancer (EOCRC) is a growing global health concern, with increasing incidence observed in China.
- Characterizing the clinicopathological and mismatch repair (MMR) features of EOCRC in Chinese populations is crucial for understanding disease progression and treatment strategies.
Purpose of the Study:
- To investigate the clinicopathological features and mismatch repair status of early-onset colorectal cancer (EOCRC) in a Chinese cohort.
- To compare EOCRC with late-onset colorectal cancer (LOCRC) and evaluate the association between early-onset status and deficient mismatch repair (dMMR).
Main Methods:
- Retrospective analysis of 23,414 colorectal neoplasia cases, including 4,159 EOCRC and LOCRC cases with complete MMR immunohistochemistry (MLH1, PMS2, MSH2, MSH6).
- Comparison of clinicopathological characteristics and MMR status between EOCRC and LOCRC groups, with stratification by family history.
- Multivariable logistic regression to assess the independent association between early-onset status and dMMR.
Main Results:
- EOCRC cases exhibited more unfavorable clinicopathological features than LOCRC, including poor differentiation, advanced T stage, and nodal involvement.
- A significantly higher prevalence of deficient mismatch repair (dMMR) was observed in EOCRC compared to LOCRC.
- Early-onset status was independently associated with dMMR, particularly in patients without a documented family history.
Conclusions:
- EOCRC in the studied Chinese cohort is characterized by more advanced clinicopathological features and a higher incidence of dMMR.
- These findings support the routine assessment of mismatch repair status in young patients diagnosed with colorectal cancer.
- Understanding MMR patterns in relation to family history can refine risk stratification and management approaches for EOCRC.
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