Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial.

JAMA neurology·2024

Same author

Preliminary reference values for Alzheimer's disease plasma biomarkers in Congolese individuals with and without dementia.

Frontiers in aging neuroscience·2024

Same author

Plasma p-tau immunoassays in clinical research for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2024

Same author

Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia.

Alzheimer's research & therapy·2024

Same author

Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2024

Same author

Increased Disability Progression in rs10191329<sup>AA</sup> Carriers with Multiple Sclerosis Is Preceded by Neurofilament Light Chain Elevations.

Annals of neurology·2024

Search research articles

Related Experiment Video

Updated: May 3, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Fluid biomarkers in multiple sclerosis: from current to future applications.

Massimiliano Di Filippo¹, Lorenzo Gaetani¹, Diego Centonze^2,3

¹Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

The Lancet Regional Health. Europe

|October 24, 2024

Summary

Fluid biomarkers in cerebrospinal fluid (CSF) and blood are revolutionizing multiple sclerosis (MS) care. These tools aid diagnosis, predict relapses, and personalize treatment for better patient outcomes.

Keywords:

Biomarkers Blood Cerebrospinal fluid Multiple sclerosis

More Related Videos

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

Published on: February 10, 2020

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

Related Experiment Videos

Last Updated: May 3, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

Published on: February 10, 2020

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

Area of Science:

Neurology
Immunology
Biochemistry

Background:

Multiple sclerosis (MS) is a complex central nervous system (CNS) disorder.
Biomarkers in cerebrospinal fluid (CSF) and blood are increasingly vital for MS management.
Advances in neurochemistry enhance disease monitoring capabilities.

Purpose of the Study:

To overview the biological basis and current use of fluid biomarkers in MS.
To explore the role of biomarkers in molecular disease characterization.
To discuss challenges and recommendations for real-world biomarker application.

Main Methods:

Review of current literature on CSF and blood biomarkers for MS.
Analysis of neurochemical advancements for detecting brain-derived proteins.
Evaluation of biomarker utility in diagnosis, prognosis, and treatment monitoring.

Main Results:

CSF analysis provides insights into MS immunopathology and aids differential diagnosis.
Fluid biomarkers can predict relapse risk and disability progression.
Detection of brain-derived proteins in blood enables efficient longitudinal monitoring.

Conclusions:

Fluid biomarkers are essential paraclinical tools for improving MS patient management.
Personalized treatment strategies can be developed using biomarker data.
Further research and standardized application are needed to maximize biomarker potential.