Related Experiment Video
Updated: Jun 9, 2025
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
466
Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure.
Virginia S Hahn1, Senthil Selvaraj2,3, Kavita Sharma1
1Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
JACC. Basic to Translational Science
|October 24, 2024
Summary
Heart failure patients show altered metabolism, particularly in fatty acids, amino acids, ketones, and glucose. Novel metabolomic approaches offer potential for personalized heart failure treatment strategies.
Area of Science:
- Cardiology
- Metabolomics
- Biochemistry
Background:
- Heart failure (HF) and cardiometabolic diseases are increasing globally.
- Metabolic dysfunction in cardiac and peripheral tissues is a key feature of HF.
- Advances in metabolomic profiling enhance understanding of metabolic flexibility in HF.
Purpose of the Study:
- To explore the role of metabolomics in understanding heart failure.
- To identify metabolic abnormalities in heart failure patients.
- To highlight novel metabolomic approaches for precision medicine in heart failure.
Main Methods:
- Comparative metabolomic profiling of heart failure patients and controls.
- Analysis of fuel metabolism pathways (fatty acids, glucose, ketones).
- Exploration of novel techniques like metabolic flux studies and single-cell analysis.
Main Results:
- Heart failure patients exhibit distinct metabolomic profiles compared to controls.
- Abnormalities observed in fatty acid, branched-chain amino acid, ketone, and glucose metabolism.
- Metabolomics identifies specific dysregulated metabolic pathways.
Conclusions:
- Metabolomic profiling is crucial for understanding heart failure pathophysiology.
- Beyond fuel metabolism, other metabolites may influence heart failure.
- Innovative metabolomic strategies are essential for advancing precision care in heart failure.
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