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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Metabolic States of the Body: Fasting and Starvation01:24

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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

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The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
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Related Experiment Video

Updated: Jun 9, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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The Association Between Intermittent Fasting and Glaucoma.

Marlow Schulz1, Leona Ding, Shu Feng

  • 1Department of Ophthalmology, University of Washington, Seattle, WA.

Journal of Glaucoma
|October 24, 2024
PubMed
Summary
This summary is machine-generated.

Intermittent fasting, or skipping breakfast, did not show a reduced risk for glaucoma diagnosis in adults over 40. Further research is needed to understand any potential links between fasting and eye health.

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Area of Science:

  • Ophthalmology
  • Nutrition Science
  • Public Health

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Intermittent fasting (IF) is a popular dietary pattern with potential systemic health effects.
  • The relationship between IF and glaucoma risk remains largely unexplored.

Purpose of the Study:

  • To investigate the association between intermittent fasting, defined as breakfast skipping, and the diagnosis of glaucoma.
  • To analyze data from a large, nationally representative US population.

Main Methods:

  • Retrospective, cross-sectional study using data from the 2005-2008 National Health and Nutrition Examination Survey (NHANES).
  • Included adult participants aged 40 years and older.
  • Glaucoma was assessed via self-report, cup-to-disc ratio (CDR) ≥0.6, and clinical judgment of retinal imaging.

Main Results:

  • The study included 7081 participants; 13.4% reported skipping breakfast.
  • Glaucoma diagnoses (by all definitions) were associated with older age and Black or Hispanic/Latinx ethnicity.
  • Intermittent fasting status was not significantly associated with glaucoma diagnosis (P=0.151).

Conclusions:

  • Intermittent fasting, characterized by breakfast skipping, was not associated with a reduced risk of glaucoma diagnosis in the studied population.
  • Additional research is warranted to explore the complex relationship between dietary patterns like IF and glaucoma development.
  • Current findings do not support IF as a preventative measure for glaucoma.