Cartilage and bone injectable hydrogels: A review of injectability methods and treatment strategies for repair in...

Cartilage and bone are crucial tissues causing disability in the elderly population, often requiring prolonged treatment and surgical intervention due to limited regenerative capacity. Injectable hydrogels that closely mimic the extracellular matrix (ECM) of native hard tissue have attracted attention due to their minimally invasive application and ability to conform to irregular defect sites. These hydrogels facilitate key biological processes such as cell migration, chondrogenesis in cartilage repair, osteoinduction, angiogenesis, osteoconduction, and mineralization in bone repair. This review analyzes in-vitro and in-vivo biomedical databases over the past decade to identify advancements in hydrogel formulations, crosslinking mechanisms, and biomaterial selection for cartilage and bone tissue engineering. The review emphasizes the effectiveness of injectable hydrogels as carriers for cells, growth factors, and drugs, offering additional therapeutic benefits. The relevance of these findings is discussed in the context of their potential to serve as a robust alternative to current surgical and non-surgical treatments. This review also examines the advantages of injectable hydrogels, such as ease of administration, reduced patient recovery time, and enhanced bioactivity, thereby emphasizing their potential in clinical applications for cartilage and bone regeneration with emphasis on addressing the shortcomings of current treatments.