The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression
Nirmalya Dasgupta1,2, Rouven Arnold3, Anais Equey3
1Center for Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA, USA. ndasgupta@lji.org.
Abstract:
Senescence and epigenetic alterations stand out as two well-characterized hallmarks of aging. When cells become senescent, they cease proliferation and release inflammatory molecules collectively termed the Senescence-Associated Secretory Phenotype (SASP). Senescence and SASP are implicated in numerous age-related diseases. Senescent cell nuclei undergo epigenetic reprogramming, which intricately regulates SASP expression. This review outlines the current understanding of how senescent cells undergo epigenetic changes and how these alterations govern SASP expression.
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