Sex Difference in 5-year Relative Survival Following Percutaneous Coronary Intervention
Jin-Ho Choi1, Jung-Min Choi2, Ki-Hong Choi3
1Department of Emergency Medicine, Samsung Medical Center Seoul, South Korea.
European Cardiology
|October 25, 2024
Summary
Female patients undergoing percutaneous coronary intervention (PCI) have lower long-term survival rates than males, especially older women. This indicates a need for improved risk reduction strategies in this demographic after PCI.
Area of Science:
- Cardiology
- Public Health
- Biostatistics
Background:
- Percutaneous coronary intervention (PCI) survival rates vary, with unclear sex-specific outcomes.
- Relative survival analysis can explain variability by comparing PCI patients to general populations.
Purpose of the Study:
- To investigate sex-specific survival outcomes after percutaneous coronary intervention (PCI).
- To assess long-term survival differences between males and females undergoing PCI using relative survival analysis.
Main Methods:
- A 2011 South Korean nationwide PCI cohort study included 48,783 patients.
- Observed and relative survival rates were assessed over 5 years, conditional on prior survival milestones.
- Propensity score-matching adjusted for sex-specific clinical characteristics.
Main Results:
- Unadjusted analyses showed lower observed and relative survival in females.
- After matching, females had higher observed survival but lower relative survival than males (HR 1.19; 95% CI [1.13-1.26]).
- This trend was more pronounced in females aged 60+ and persisted across follow-up periods.
Conclusions:
- Older females undergoing PCI exhibit lower 5-year relative survival compared to age-matched males.
- There is a need for enhanced risk reduction strategies for older females post-PCI.
Related Concept Videos
01:20Comparing the Survival Analysis of Two or More Groups
155
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
155
01:27Coronary Artery Disease V: Surgical Management
3
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
3
01:30Acute Coronary SyndromeI: Introduction
3
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
3